Department of Pharmacy Practice

Department of Pharmacy Practice and Science

Chronic Kidney Disease

Research in patients with chronic kidney disease is yielding new information on how the kidneys play a role in the metabolism of many drugs for short-term illnesses and chronic disease. Thomas Dowling, PharmD,PhD, is associate professor, PPS vice chair of research and associate director of the Clinical Pharmacology Unit. His research aim is to maximize treatment effectiveness and avoid unwanted side effects in people with kidney disease. Dowling’s investigations include sensitive measurement of the kidney’s response to medications in serious conditions such as congestive heart failure, kidney transplantation and hepatitis. Dowling and Assistant Professor Chanel Agness, PharmD, are collaborating with Michael K. Hise, MD associate professor and chief of nephrology at the Baltimore VA Medical Center, to determine the role of genetic variability in drug response and metabolism among select subpopulations of patients.

Refer to the recent PPS faculty publications below to find out more about our research in chronic kidney disease:

Dittrich HC, Gupta DK, Hack TC, Dowling T, Callahan J, Thomson S. The effect of KW-3902, an adenosine A1 receptor antagonist, on renal function and renal plasma flow in ambulatory patients with heart failure and renal impairment. J Card Fail 2007 Oct;13(8):609-17.

Dowling TC. Prevalence, etiology, and consequences of anemia and clinical and economic benefits of anemia correction in patients with chronic kidney disease: an overview. Am J Health Syst Pharm 2007 Jul 1;64(13 Suppl 8):S3-7.

Dowling TC. Quantification of renal function. In: Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, editors. Pharmacotherapy: a pathopshyiologic approach. 7th ed. New York: McGraw-Hill; 2008.

Howell CD, Dowling TC, Paul M, et al. Evaluation of racial differences in peginterferon alpha 2a pharmacokinetics and virologic response in patients with chronic hepatitis C genotype 1. Clin Gastroenterol Hepatol 2008 May;6(5):575-83.

Jones JM, Dowling TC, Park JJ, Phares DA, Park JY, Obisesan T, Brown MD. Differential aerobic exercise-induced changes in plasma aldosterone between African American and White prehypertensives & hypertensives may be dependent on baseline plasma aldosterone levels. Exp Physiol 2007 May.

Jones JM, Dowling TC, Park JJ, Roth S, Phares DA, Park JY, Brown MD. Differential aerobic exercise-induced changes in plasma aldosterone between African Americans and Whites. Exp Physiol 2007 Sep;92(5):871-9.

Jones-Burton C, Vessal G, Dowling TC, Brown J, Fink JC. Urinary continence as an objective measure of cigarette smoking in chronic kidney disease. Nephrol Dial Transplant 2007 Jul;22(7):1950-4.