Michael J. Shapiro, PhD

20 Penn Street Health Sciences Facility Room 633 Baltimore, MD 21201 410-706-5928 - phone 410-706-5017 - fax mshapiro@rx.umaryland.edu

Application and development of NMR methodologies and strategies and their corresponding utility to understand the structure and function of therapeutic proteins in structure-based drug design programs. Of particular interest are the topics of conformational selection and adaptive proteins 2) Protein NMR chemical shifts and relaxation parameters to understand ligand-protein interactions. 3) NMR and biophysical methods in drug discovery using fragment based drug design.